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1 · Step by step: towards a better understanding of the genetic
2 · Rare coding variants in PLCG2, ABI3 and TREM2 implicate
3 · New insights into the genetic etiology of Alzheimer’s disease and
4 · New insights into the genetic etiology of Alzheimer's disease and
5 · Genetics of Alzheimer's disease: where we are, and where we
6 · Céline Bellenguez (0000
7 · Céline Bellenguez
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celine bellenguez*******Céline Bellenguez 1 , Benjamin Grenier-Boley 1 , Jean-Charles Lambert 2. Affiliations. 1 Univ. Lille, Inserm, Institut Pasteur de Lille, CHU Lille, U1167 - Labex DISTALZ - RID .author = "C{\'e}line Bellenguez and Fahri K{\"u}{\c c}{\"u}kali and Jansen, {Iris E.} and Luca Kleineidam and Sonia Moreno-Grau and Najaf Amin and Naj, {Adam C.} and Rafael .
Céline Bellenguez via Europe PubMed Central. X-Chromosome-wide association study for Alzheimer’s disease. 2024-05 | Preprint. DOI: 10.1101/2024.05.02.24306739. . Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk .
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the .
Bellenguez, Céline ; Küçükali, Fahri ; Jansen, Iris E. et al. / New insights into the genetic etiology of Alzheimer’s disease and related dementias. In: Nature Genetics. 2022 ; Vol. .
celine bellenguez Step by step: towards a better understanding of the genetic Céline Bellenguez. Molecular Psychiatry 28, 2716–2727 (2023) Cite this article. 10k Accesses. 20 Citations. 32 Altmetric. Metrics. Abstract. Alzheimer’s disease .Céline Bellenguez. EADB. Inserm,InstitutPasteurdeLille,Lille,France. Abstract. lowing quality control, including 8,633,349 common variants (minor allele frequency (MAF) .celine bellenguezFrom the same brain tissue, we examined methylation (n=714) 16 and H3K9ac acetylation (n=676) data and found differential methylation at four CpG sites and lower acetylation at .Published: 04 April 2022. New insights into the genetic etiology of Alzheimer’s disease and related dementias. Céline Bellenguez, Fahri Küçükali, Iris E. Jansen, Luca Kleineidam, Sonia.
Céline Bellenguez 1 , Benjamin Grenier-Boley 1 , Jean-Charles Lambert 2. Affiliations. 1 Univ. Lille, Inserm, Institut Pasteur de Lille, CHU Lille, U1167 - Labex DISTALZ - RID-AGE - Risk Factors and Molecular Determinants of Aging-Related Diseases, F-59000 Lille, France.author = "C{\'e}line Bellenguez and Fahri K{\"u}{\c c}{\"u}kali and Jansen, {Iris E.} and Luca Kleineidam and Sonia Moreno-Grau and Najaf Amin and Naj, {Adam C.} and Rafael Campos-Martin and Benjamin Grenier-Boley and Victor Andrade and Holmans, {Peter A.} and Anne Boland and Vincent Damotte and {van der Lee}, {Sven J.} and Costa, {Marcos .Céline Bellenguez via Europe PubMed Central. X-Chromosome-wide association study for Alzheimer’s disease. 2024-05 | Preprint. DOI: 10.1101/2024.05.02.24306739. PPR: PPR847822. Contributors: Le Borgne J; Gomez L; Heikkinen S; Amin N; Ahmad S; Choi SH; Bis J; Grenier-Boley B; Rodriguez OG; Kleineidam L et al. Show more detail. .
Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'pro ..Bellenguez, Céline ; Küçükali, Fahri ; Jansen, Iris E. et al. / New insights into the genetic etiology of Alzheimer’s disease and related dementias. In: Nature Genetics. 2022 ; Vol. 54, No. 4. pp. 412-436. Céline Bellenguez. Molecular Psychiatry 28, 2716–2727 (2023) Cite this article. 10k Accesses. 20 Citations. 32 Altmetric. Metrics. Abstract. Alzheimer’s disease (AD) is considered to have a.Céline Bellenguez. EADB. Inserm,InstitutPasteurdeLille,Lille,France. Abstract. lowing quality control, including 8,633,349 common variants (minor allele frequency (MAF) above 1%), and 1,324,211 low frequency variants (MAF range between 0.5% and 1%). We identified 57 loci with at least suggestive evidence (P 1 10−. ×.From the same brain tissue, we examined methylation (n=714) 16 and H3K9ac acetylation (n=676) data and found differential methylation at four CpG sites and lower acetylation at two H3K9ac sites adjacent to PLCG2 and ABI3 in relation to increased global neuritic plaque and tangle burden (FDR < 0.05).
Published: 04 April 2022. New insights into the genetic etiology of Alzheimer’s disease and related dementias. Céline Bellenguez, Fahri Küçükali, Iris E. Jansen, Luca Kleineidam, Sonia.Céline Bellenguez 1 , Benjamin Grenier-Boley 1 , Jean-Charles Lambert 2. Affiliations. 1 Univ. Lille, Inserm, Institut Pasteur de Lille, CHU Lille, U1167 - Labex DISTALZ - RID-AGE - Risk Factors and Molecular Determinants of Aging-Related Diseases, F-59000 Lille, France.author = "C{\'e}line Bellenguez and Fahri K{\"u}{\c c}{\"u}kali and Jansen, {Iris E.} and Luca Kleineidam and Sonia Moreno-Grau and Najaf Amin and Naj, {Adam C.} and Rafael Campos-Martin and Benjamin Grenier-Boley and Victor Andrade and Holmans, {Peter A.} and Anne Boland and Vincent Damotte and {van der Lee}, {Sven J.} and Costa, {Marcos .
Céline Bellenguez via Europe PubMed Central. X-Chromosome-wide association study for Alzheimer’s disease. 2024-05 | Preprint. DOI: 10.1101/2024.05.02.24306739. PPR: PPR847822. Contributors: Le Borgne J; Gomez L; Heikkinen S; Amin N; Ahmad S; Choi SH; Bis J; Grenier-Boley B; Rodriguez OG; Kleineidam L et al. Show more detail. . Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'pro ..Bellenguez, Céline ; Küçükali, Fahri ; Jansen, Iris E. et al. / New insights into the genetic etiology of Alzheimer’s disease and related dementias. In: Nature Genetics. 2022 ; Vol. 54, No. 4. pp. 412-436.
Céline Bellenguez. Molecular Psychiatry 28, 2716–2727 (2023) Cite this article. 10k Accesses. 20 Citations. 32 Altmetric. Metrics. Abstract. Alzheimer’s disease (AD) is considered to have a.
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celine bellenguez|Step by step: towards a better understanding of the genetic